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New Synthetic Isoxazole Derivatives Acting as Potent Inducers of Fetal Hemoglobin in Erythroid Precursor Cells Isolated from β-Thalassemic Patients
Zuccato, Cristina; Cosenza, Lucia Carmela; Tupini, Chiara; Finotti, Alessia; Sacchetti, Gianni; Simoni, Daniele; Gambari, Roberto; Lampronti, Ilaria     dettagli >>
MOLECULES
Vol. 29, No. 1, pp: 8-1-8-16, Anno: 2024

Inhibitory effects of SARS-CoV-2 spike protein and BNT162b2 vaccine on erythropoietin-induced globin gene expression in erythroid precursor cells from patients with β-thalassemia
Cosenza, Lucia Carmela; Marzaro, Giovanni; Zurlo, Matteo; Gasparello, Jessica; Zuccato, Cristina; Finotti, Alessia; Gambari, Roberto     dettagli >>
EXPERIMENTAL HEMATOLOGY
Vol. 129, No. 1, pp: 104128-104143, Anno: 2024

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus
Zurlo, Matteo; Zuccato, Cristina; Cosenza, Lucia Carmela; Gasparello, Jessica; Gamberini, Maria Rita; Stievano, Alice; Fortini, Monica; Prosdocimi, Marco; Finotti, Alessia; Gambari, Roberto     dettagli >>
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Vol. 24, No. 20, pp: 15049-15049, Anno: 2023

MicroRNAs miR-584-5p and miR-425-3p Are Up-Regulated in Plasma of Colorectal Cancer (CRC) Patients: Targeting with Inhibitor Peptide Nucleic Acids Is Associated with Induction of Apoptosis in Colon Cancer Cell Lines
Gasparello, Jessica; Papi, Chiara; Zurlo, Matteo; Gambari, Laura; Manicardi, Alex; Rozzi, Andrea; Ferrarini, Matteo; Corradini, Roberto; Gambari, Roberto; Finotti, Alessia     dettagli >>
CANCERS
Vol. 15, No. 1, pp: 128-1-128-16, Anno: 2023

Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy
Zurlo, Matteo; Gasparello, Jessica; Cosenza, Lucia Carmela; Breveglieri, Giulia; Papi, Chiara; Zuccato, Cristina; Gambari, Roberto; Finotti, Alessia     dettagli >>
GENES
Vol. 14, No. 3, pp: 556-572, Anno: 2023

Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences
Finotti, Alessia; Gasparello, Jessica; Zuccato, Cristina; Cosenza, Lucia Carmela; Fabbri, Enrica; Bianchi, Nicoletta; Gambari, Roberto     dettagli >>
GENES
Vol. 14, No. 10, pp: 1927-1927, Anno: 2023

Effects of Sirolimus Treatment on Fetal Hemoglobin Production and Response to SARS-CoV-2 Vaccination: A Case Report Study
Gamberini, Maria Rita; Zuccato, Cristina; Zurlo, Matteo; Cosenza, Lucia Carmela; Finotti, Alessia; Gambari, Roberto     dettagli >>
HEMATOLOGY REPORTS
Vol. 15, No. 3, pp: 432-439, Anno: 2023

SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation
Bezzerri, Valentino; Gentili, Valentina; Api, Martina; Finotti, Alessia; Papi, Chiara; Tamanini, Anna; Boni, Christian; Baldisseri, Elena; Olioso, Debora; Duca, Martina; Tedesco, Erika; Leo, Sara; Borgatti, Monica; Volpi, Sonia; Pinton, Paolo; Cabrini, Giulio; Gambari, Roberto; Blasi, Francesco; Lippi, Giuseppe; Rimessi, Alessandro; Rizzo, Roberta; Cipolli, Marco     dettagli >>
NATURE COMMUNICATIONS
Vol. 14, No. 1, pp: 132-1-132-15, Anno: 2023

The Cystic Fibrosis Transmembrane Conductance Regulator Gene (CFTR) Is under Post-Transcriptional Control of microRNAs: Analysis of the Effects of agomiRNAs Mimicking miR-145-5p, miR-101-3p, and miR-335-5p
Papi, Chiara; Gasparello, Jessica; Zurlo, Matteo; Cosenza, Lucia Carmela; Gambari, Roberto; Finotti, Alessia     dettagli >>
NON-CODING RNA
Vol. 9, No. 2, pp: 1-11, Anno: 2023

Effects of Sirolimus treatment on patients with β-Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4+ and CD8+ T cells
Zurlo, Matteo; Nicoli, Francesco; Proietto, Davide; Dallan, Beatrice; Zuccato, Cristina; Cosenza, Lucia Carmela; Gasparello, Jessica; Papi, Chiara; D'Aversa, Elisabetta; Borgatti, Monica; Scapoli, Chiara; Finotti, Alessia; Gambari, Roberto     dettagli >>
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Vol. 27, No. 3, pp: 353-364, Anno: 2023

Cationic Calix[4]arene Vectors to Efficiently Deliver AntimiRNA Peptide Nucleic Acids (PNAs) and miRNA Mimics
Gasparello, Jessica; Papi, Chiara; Zurlo, Matteo; Volpi, Stefano; Gambari, Roberto; Corradini, Roberto; Casnati, Alessandro; Sansone, Francesco; Finotti, Alessia     dettagli >>
PHARMACEUTICS
Vol. 15, No. 8, pp: 2121-2121, Anno: 2023

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
Zuccato, Cristina; Cosenza, Lucia Carmela; Zurlo, Matteo; Breveglieri, Giulia; Bianchi, Nicoletta; Lampronti, Ilaria; Gasparello, Jessica; Scapoli, Chiara; Borgatti, Monica; Finotti, Alessia; Gambari, Roberto     dettagli >>
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Vol. 24, No. 1, pp: 776-1-776-11, Anno: 2023

Combined Treatment of Cancer Cells Using Allyl Palladium Complexes Bearing Purine-Based NHC Ligands and Molecules Targeting MicroRNAs miR-221-3p and miR-222-3p: Synergistic Effects on Apoptosis
Tupini, Chiara; Zurlo, Matteo; Gasparello, Jessica; Lodi, Irene; Finotti, Alessia; Scattolin, Thomas; Visentin, Fabiano; Gambari, Roberto; Lampronti, Ilaria     dettagli >>
PHARMACEUTICS
Vol. 15, No. 5, pp: 1332-1-1332-17, Anno: 2023

The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies
Gambari, Roberto; Zuccato, Cristina; Cosenza, Lucia Carmela; Zurlo, Matteo; Gasparello, Jessica; Finotti, Alessia; Gamberini, Maria Rita; Prosdocimi, Marco     dettagli >>
BIOLOGY
Vol. 12, No. 9, pp: 1202-1202, Anno: 2023

Combined approaches for increasing fetal hemoglobin (HbF) and de novo production of adult hemoglobin (HbA) in erythroid cells from β-thalassemia patients: treatment with HbF inducers and CRISPR-Cas9 based genome editing
Finotti, Alessia; Gambari, Roberto     dettagli >>
FRONTIERS IN GENOME EDITING
Vol. 5, No. 1, pp: 1204536-1204549, Anno: 2023

The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-fetal globin genes in human erythroleukemia K562 cells
Zurlo, Matteo; Gasparello, Jessica; Verona, Marco; Papi, Chiara; Cosenza, Lucia Carmela; Finotti, Alessia; Marzaro, Giovanni; Gambari, Roberto     dettagli >>
EXPERIMENTAL CELL RESEARCH
Vol. 433, No. 2, pp: 113853-113864, Anno: 2023

Effects of Sulforaphane on SARS‑CoV‑2 infection and NF‑κB dependent expression of genes involved in the COVID‑19 'cytokine storm'
Gasparello, Jessica; Marzaro, Giovanni; Papi, Chiara; Gentili, Valentina; Rizzo, Roberta; Zurlo, Matteo; Scapoli, Chiara; Finotti, Alessia; Gambari, Roberto     dettagli >>
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Vol. 52, No. 3, pp: 76-1-76-14, Anno: 2023

A Rational Approach to Drug Repositioning in β-thalassemia: Induction of Fetal Hemoglobin by Established Drugs
Prosdocimi, Marco; Zuccato, Cristina; Cosenza, Lucia Carmela; Borgatti, Monica; Lampronti, Ilaria; Finotti, Alessia; Gambari, Roberto     dettagli >>
WELLCOME OPEN RESEARCH
Vol. 7, No. 1, pp: 150-1-150-18, Anno: 2022

Treatment of Human Glioblastoma U251 Cells with Sulforaphane and a Peptide Nucleic Acid (PNA) Targeting miR-15b-5p: Synergistic Effects on Induction of Apoptosis
Gasparello, J.; Papi, C.; Zurlo, M.; Gambari, L.; Rozzi, A.; Manicardi, A.; Corradini, R.; Gambari, R.; Finotti, A.     dettagli >>
MOLECULES
Vol. 27, No. 4, pp: 1299-1-1299-18, Anno: 2022

Teaching during COVID-19 pandemic in practical laboratory classes of applied biochemistry and pharmacology: A validated fast and simple protocol for detection of SARS-CoV-2 Spike sequences
Gasparello, Jessica; Papi, Chiara; Zurlo, Matteo; Cosenza, Lucia Carmela; Breveglieri, Giulia; Zuccato, Cristina; Gambari, Roberto; Finotti, Alessia     dettagli >>
PLOS ONE
Vol. 17, No. 4, pp: 0266419-1-0266419-17, Anno: 2022

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